|Názov:||Alignment of Nanopore Sequencing Reads
|Vedúci:||Mgr. Tomáą Vinař,PhD.
|Kµúčové slová:||hidden Markov models, nanopore sequencing, alignment of reads
|Abstrakt:||Nanopore sequencing is a DNA sequencing technology of the most recent generation.
It is known by its ability to produce long reads which are prone to errors. In this
bachelor thesis we study the alignment of these high error rate reads.
The alignment of the nanopore reads is usually performed in two steps. First, we
need to infer the DNA sequence from the data produced by the nanopore sequencing
device and then we use a general-purpose alignment algorithm. However, the process
of DNA sequence inference is prone to errors. Therefore much information is lost
during this process. We propose an approach which tries to eliminate the loss of this
information and tries to use it for the alignment.
Súbory bakalárskej práce: