Názov:Alignment of Nanopore Sequencing Reads
Vedúci:Mgr. Tomáą Vinař,PhD.
Kµúčové slová:hidden Markov models, nanopore sequencing, alignment of reads
Abstrakt:Nanopore sequencing is a DNA sequencing technology of the most recent generation. It is known by its ability to produce long reads which are prone to errors. In this bachelor thesis we study the alignment of these high error rate reads. The alignment of the nanopore reads is usually performed in two steps. First, we need to infer the DNA sequence from the data produced by the nanopore sequencing device and then we use a general-purpose alignment algorithm. However, the process of DNA sequence inference is prone to errors. Therefore much information is lost during this process. We propose an approach which tries to eliminate the loss of this information and tries to use it for the alignment.

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